Real Madrid vs Osasuna: 2025 La Liga Opener Odds, Predictions, and Mbappe’s Big Debut

All Eyes on Real Madrid’s Home Opener Against Osasuna

Kicking off the 2025-26 La Liga season, Real Madrid welcomes Osasuna to Santiago Bernabeu. This isn’t just your average league opener. Madrid comes off a campaign where they fell just four points short of top spot, ending second behind their biggest rivals, Barcelona. Osasuna finished solidly in ninth. The stage is set for new beginnings, bigger ambitions, and a very familiar expectation: Madrid dominance—especially at home.

Madrid's pre-season went just as they’d want with a bold 4-0 win over WSG Tirol. Osasuna wasn’t far behind, securing a comfortable 3-0 result against Mirandes. It’s obvious both teams hit the ground running, but let’s be honest: the difference in firepower and depth is huge.

The Odds Paint a Clear Picture

If you glance at the betting markets, Madrid’s favoritism leaps off the page. At -500, you have to put down $500 just to win $100 if you think the home side will take the points. Osasuna’s +1000 odds spell out what most expect—a tough night ahead. A draw? That's going at +550, so it isn’t likely in the eyes of the bookies.

The total goals over/under line is set at 3.5, backing the belief that this game will feature an attacking show. Vinicius Junior, fresh from a strong pre-season, is priced at -165 to score or assist. But he’s not the only one with eyes on him. It’s the arrival of Kylian Mbappe that’s got Madrid fans and bettors buzzing.

Mbappe’s debut is the headline. The French superstar, who finally made his long-anticipated move to Spain, gets the chance to sparkle right out of the gate. You like him to make an instant impact? Oddsmakers agree: Mbappe is –135 to score anytime (so, not much value, but a lot of belief in his threat). If you’re after higher risk, you could back Mbappe to score two or more at +250—a tempting boost if he gets into stride early.

Even the team scoring line tells a story. “Madrid to score over 2.5 goals” is at even money (+100). Considering their preseason and the attacking weapons in their arsenal, the expectation is a pretty open game, tilted towards the home side filling up the scoresheet.

For those of you who follow tipsters, Jon "Buckets" Eimer, who’s got a solid record as a top soccer analyst, is all-in on Madrid’s offensive potential in this one. He likes Mbappe as an anytime goal-scorer, throws in odds for a possible Mbappe brace, and sees Madrid pushing past the 2.5 team goal mark. His confidence comes off the back of years of profitable picks in domestic and European leagues, so he’s not some random guy throwing out hot takes.

Madrid fans can expect a celebratory mood at the Bernabeu, with a shiny new star leading the line and the promise of goals. Osasuna will look to spoil the show, but the odds—and the talent on the pitch—say the task ahead is monumental. One thing’s certain: this opener is no friendly. There’s a lot to prove, and Real Madrid has no shortage of reasons to set the tone for the long season ahead.